New Blood Markers Predict Kidney Disease and Mortality in Diabetes

Kidney complications in diabetes can progress silently, posing risks of severe outcomes before symptoms show. Identifying diabetes patients at risk of rapid kidney decline or early death has been a challenge. Traditional markers like serum creatinine and urinary albumin have limitations in predicting these risks.

A recent study published in the Journal of Cachexia, Sarcopenia and Muscle on August 1, 2025, introduces a potential solution. Researchers led by Associate Professor Tomohito Gohda from Juntendo University Faculty of Medicine found that two blood markers, eGFRdiff and GDF-15, can predict kidney disease progression and mortality in diabetes patients. These markers complement existing ones, aiding in the early identification of high-risk patients.

The study analyzed data from 638 Japanese adults with diabetes over 5 years. Lower eGFRdiff values were linked to higher risk of chronic kidney disease progression, while elevated GDF-15 levels were associated with increased mortality risk. Combining these markers could enhance precision in identifying vulnerable patients.

Early detection using eGFRdiff and GDF-15 could lead to tailored interventions, potentially preventing disease progression and saving lives. These markers offer insights into frailty and inflammation, contributing to CKD progression and mortality in diabetes patients.

This study provides hope for improved care in diabetes, crucial as diabetes rates rise globally.

According to the source: News-Medical.