Study: Vitamin C boosts skin thickness by activating growth genes
A recent study from Japan reveals that Vitamin C can help thicken the skin by activating genes responsible for skin cell growth. The research, led by Dr. Akihito Ishigami, highlights the potential of Vitamin C in promoting skin renewal and strengthening. The findings were published in the Journal of Investigative Dermatology.

This study highlights the benefits of vitamin C (VC) in promoting skin health and thickening the skin by activating genes that control skin cell growth and development. The research, led by Dr. Akihito Ishigami from Tokyo Metropolitan Institute for Geriatrics and Gerontology (TMIG), Japan, suggests that VC may restore skin function by reactivating genes essential for epidermal renewal.
The researchers used human epidermal equivalents to demonstrate that VC promotes cell proliferation and differentiation by promoting DNA demethylation. By sustaining the function of TET enzymes, VC helps in gene expression, cell growth, and differentiation. The study identified over 10,138 hypomethylated differentially methylated regions in VC-treated skin and observed increased expression of key proliferation-related genes.
These findings indicate that VC can support skin renewal by triggering genetic pathways involved in growth and repair, making it a promising treatment for thinning skin, especially in older adults. The research suggests that VC may boost the skin's natural capacity to regenerate and strengthen itself.
According to the source: Medical Xpress.
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