Study Launched to Investigate Side Effects of Weight Loss Injections on Pancreas Health

A study has been launched to investigate potential serious side effects of weight loss jabs after reports of pancreas problems. The Medicines and Healthcare Regulatory Agency (MHRA) and Genomics England are seeking input from individuals who have experienced acute pancreatitis while on weight loss drugs. Although there have been numerous reports of pancreatitis linked to drugs like Mounjaro, Ozempic, and Wegovy, no direct causation has been confirmed.

The study aims to identify individuals at higher risk of adverse reactions. Patients who have had negative reactions to weight loss jabs, also used for type 2 diabetes, are encouraged to report their experiences on the Yellow Card website. Those willing to participate will provide additional information and a saliva sample to determine genetic predispositions to pancreatitis.

Health officials highlight the potential of weight loss drugs in combating obesity but caution about associated side effects like nausea, constipation, and diarrhea. The MHRA warns that Mounjaro may reduce the effectiveness of the oral contraceptive pill for some users.

Dr. Alison Cave, MHRA's chief safety officer, emphasizes the importance of genetic testing in predicting adverse reactions and ensuring patient safety. The study aims to prevent a significant portion of medication side effects, potentially saving the NHS billions annually.

Prof Matt Brown from Genomics England underscores the need for personalized approaches to medication to minimize risks and enhance effectiveness. The goal is to gather data for safer treatments and support a preventive healthcare model.