New Pocket-Size Model of ALS Holds Promise for Treatment Development

Scientists have developed a pocket-sized model of amyotrophic lateral sclerosis (ALS), the most common form of the disease. This 'disease-on-a-chip' made from stem cells could lead to new treatments for ALS, a condition where motor neurons in the brain and spinal cord break down, causing muscle weakness and paralysis.

The model, described in a study published in Cell Stem Cell, mimics sporadic ALS, accounting for most cases without a clear genetic cause. By reprogramming blood cells into induced pluripotent stem cells (iPSCs) and then into spinal motor neurons, researchers created a platform that accurately represents early disease stages.

The chip, developed by Emulate and customized by Cedars-Sinai researchers, features flowing fluids that help neurons mature and differentiate between healthy and ALS cells. The model revealed abnormal glutamate signaling in ALS neurons, a potential trigger for degeneration.

While the model lacks certain nervous system cells and late-stage degeneration, it shows promise for early drug screening and understanding disease pathways. Future goals include extending cell maintenance and incorporating additional cell types to mimic ALS progression.

According to the source: Live Science.